张健，理学博士，长聘副教授，入选天津大学“北洋学者英才计划”。研究方向聚焦于组学大数据深度挖掘与解析研究，旨在通过开发先进的生物信息学及机器学习技术，推动重大疾病的精准诊断及个性化治疗。在Nature Genetics, Nature Biotechnology, Cell Stem Cell, Genome Medicine, Journal for Immunotherapy of Cancer等国际学术期刊发表论文18篇，研究成果入选美国癌症研究协会年度主会议报告(AACR, 2018)和国际抗体研究联盟邀请报告(AIRR, 2019)。承担和参与完成科技部国家重点研发项目、国家863计划项目、国家自然科学基金项目等多个课题。现任中国自动化学会智能健康与生物信息专委会委员、中国生物工程学会计算生物学与生物信息学专业委员会委员。

生物信息学、机器学习与人工智能、计算癌症免疫

[1]  Qin J#, Zhang J#, Jiang J#, Zhang B, Li J, Lin X, Wang S, Zhu M, Fan Z, Lv Y, He L, Chen L, Yue W, Li Y*, Pei X*. Direct chemical reprogramming of human cord blood erythroblasts to induced megakaryocytes that produce platelets[J]. Cell Stem Cell, 2022, 29(8): 1229-1245.e7.

[2]  Xing X#, Shi J#, Jia Y#, Dou Y#, Li Z#, Dong B, Guo T, Cheng X, Li X, Du H, Hu Y, Jia S*, Zhang J*, Li Z*, Ji J*. Effect of neoadjuvant chemotherapy on the immune microenvironment in gastric cancer as determined by multiplex immunofluorescence and T cell receptor repertoire analysis[J]. Journal for ImmunoTherapy of Cancer, 2022, 10(3): e003984.

[3]  Wang H#, Feng C#, Lu M, Zhang B, Xu Y, Zeng Q, Xi J, Zhou J, Ying X, Zhang J*, Yue W*, Pei X*. Integrative single-cell transcriptome analysis reveals a subpopulation of fibroblasts associated with favorable prognosis of liver cancer patients[J]. Translational Oncology, 2021, 14(1): 100981.

[4]  Zhang J, Hu X, Wang J, Sahu A D, Cohen D, Song L, Ouyang Z, Fan J, Wang B, Fu J, Gu S, Sade-Feldman M, Hacohen N, Li W, Ying X*, Li B*, Liu X S*. Immune receptor repertoires in pediatric and adult acute myeloid leukemia[J]. Genome Medicine, 2019, 11(1): 73.

[5]  Hu X#, Zhang J#, Wang J, Fu J, Li T, Zheng X, Wang B, Gu S, Jiang P, Fan J, Ying X, Zhang J, Carroll M C, Wucherpfennig K W, Hacohen N, Zhang F, Zhang P, Liu J S*, Li B*, Liu X S*. Landscape of B cell immunity and related immune evasion in human cancers[J]. Nature Genetics, 2019, 51(3): 560–567.

[6]  Zhang J, Qian L, Wu J, Lu D, Yuan H, Li W, Ying X*, Hu S*. Up-regulation of FAM64A promotes epithelial-to-mesenchymal transition and enhances stemness features in breast cancer cells[J]. Biochemical and Biophysical Research Communications, 2019，513(2): 472–478.

[7]  Hu X#, Zhang J#, Liu J S, Li B*, Liu X S*. Evaluation of immune repertoire inference methods from RNA-seq data[J]. Nature Biotechnology, 2018, 36(11): 1034–1034.

[8]  Zhang H#, Liu L#, Zhang J, Chen J, Ye J, Shukla S, Qiao J, Zhan X, Chen H, Wu C J, Fu Y-X*, Li B*. Investigation of Antigen-Specific T-Cell Receptor Clusters in Human Cancers[J]. Clinical Cancer Research, 2020, 26(6): 1359–1371.

[9]  Li B, Li T, Wang B, Dou R, Zhang J, Liu J S, Liu X S. Ultrasensitive detection of TCR hypervariable-region sequences in solid-tissue RNA–seq data[J]. Nature Genetics, 2017, 49(4): 482–483.

[10]      Li T, Chen L, Cheng J, Dai J, Huang Y, Zhang J, Liu Z, Li A, Li N, Wang H, Yin X, He K, Yu M, Zhou T, Zhang X, Xia Q. SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores[J]. Nature Communications, 2016, 7: 12969.

1．2020-2021，天津大学北洋学者英才计划基金项目，《基于外周血RNA测序数据的结核病诊断免疫标志物研究及预测模型构建》，负责人。

2. 2021-2023，国家自然科学基金青年项目，《免疫组库分析算法及其在结核病精准诊疗中的应用研究》，负责人

2020年 入选天津大学-北洋学者英才计划

2016年 国家留学基金委公派留学资助

2014年 第五届中美临床与转化医学国际论坛研究生论文奖

2013年 第十二届“挑战杯”天津市大学生课外学术科技作品竞赛一等奖

中国自动化学会智能健康与生物信息专委会委员

中国生物工程学会计算生物学与生物信息学专业委员会委员

中国免疫学会会员