副教授/副研究员

张健

职称:副教授

邮箱:jian_zhang@tju.edu.cn

电话:022-83612122

地址:天津大学医工院10号楼404室

个人简介

张健,博士,副教授,入选天津大学-北洋学者英才计划。主要聚焦于生物医学大数据(分子组学数据)处理与分析关键技术,重点面向肿瘤精准医疗和传染病防控安全实际需求开展研究工作。近年来以技术骨干、参与人身份参加了5项包括国家科技重大专项、国防科技创新特区项目、国家自然科学基金委面上项目以及国家863计划项目的实施;发表SCI期刊论文13篇,其中以第一作者(含并列第一)身份在包括Nature Genetics, Nature Biotechnology, Genome Medicine在内的权威国际期刊发表论文4篇,以署名作者身份在Nature Genetics, Nature Communication, Clinical Cancer Research等杂志发表论文9篇,平均影响因子11.868,谷歌H指数8。

 

教育背景

2016.12-2018.04,哈佛大学Dana-Farber癌症研究所,生物统计与计算生物学系,访问

2013.09-2018.06,军事科学院军事医学研究院,生物信息学,博士 

2009.09-2013.06,南开大学,计算机科学与技术,学士

 

工作经历

2020.04 - 今,天津大学医学工程与转化医学研究院,副教授

2018.06 - 2020.01,军事科学院军事医学研究院,助理研究员

 

主要研究方向

生物信息学、组学大数据挖掘与建模、计算免疫学技术与方法

 

代表性学术成果

1. J. Zhang, X. Hu, J. Wang, A. Das Sahu, D. Cohen, J. Fan, B. Wang, J. Fu, S. Gu, M. Sade-Feldman, N. Hacohen, W. Li, X. Ying, B. Li, X.S. Liu, Immune receptor repertoires in pediatric and adult acute myeloid leukemia, Genome Medicine. (2019).

2. X. Hu*, J. Zhang*, J. Wang, J. Fu, T. Li, X. Zheng, B. Wang, S. Gu, P. Jiang, J. Fan, X. Ying, J. Zhang, M.C. Carroll, K.W. Wucherpfennig, N. Hacohen, F. Zhang, P. Zhang, J.S. Liu, B. Li, X.S. Liu, Landscape of B cell immunity and related immune evasion in human cancers, Nature Genetics. (2019). *Co-First

3. X. Hu*, J. Zhang*, J.S. Liu, B. Li, X.S. Liu, Evaluation of immune repertoire inference methods from RNA-seq data, Nature Biotechnology. 36 (2018) 1034–1034. *Co-First

4. J. Zhang, L. Qian, J. Wu, D. Lu, H. Yuan, W. Li, X. Ying, S. Hu, Up-regulation of FAM64A promotes epithelial-to-mesenchymal transition and enhances stemness features in breast cancer cells, Biochemical and Biophysical Research Communications. (2019).

5. B. Li, T. Li, B. Wang, R. Dou, J. Zhang, J.S. Liu, X.S. Liu, Ultrasensitive detection of TCR hypervariable-region sequences in solid-tissue RNA-seq data, Nature Genetics. 49 (2017) 482–483.

6. H. Zhang, L. Liu, J. Zhang, J. Chen, J. Ye, S. Shukla, J. Qiao, X. Zhan, H. Chen, C. Wu, Y. Fu, B. Li, Investigation of Antigen-Specific T-Cell Receptor Clusters in Human Cancers, Clinical Cancer Research. 2020, 26(6): 1359–1371.

7. S. Haihua Chu, Jonathan R. Chabon, Chloe N. Matovina, Janna C. Minehart, Bo-Ruei Chen, J. Zhang, Vipul Kumar, Elsa Callen-Moreu, Putzer J Hung, Zhaohui Feng, Richard P. Koche, X. Shirley Liu, Jayanta Chaudhuri, Andre Nussenzweig, Barry P. Sleckman, and Scott A. Armstrong. Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development. iScience, 2020, 23(3): 100941.

8. M. Cornwell, M. Vangala, L. Taing, Z. Herbert, J. Köster, B. Li, H. Sun, T. Li, J. Zhang, X. Qiu, M. Pun, R. Jeselsohn, M. Brown, X.S. Liu, H.W. Long, VIPER: Visualization Pipeline for RNA-seq, a Snakemake workflow for efficient and complete RNA-seq analysis, BMC Bioinformatics. 19 (2018) 135.

9. X. Xing, J. Guo, G. Ding, B. Li, B. Dong, Q. Feng, S. Li, J. Zhang, X. Ying, X. Cheng, T. Guo, H. Du, Y. Hu, T. Zhou, X. Wang, L. Li, Q. Li, M. Xie, L. Li, X. Gao, F. Shan, Z. Li, S. Jia, X. Wen, J. Wang, J. Ji, Analysis of PD1, PDL1, PDL2 expression and T cells infiltration in 1014 gastric cancer patients, OncoImmunology. 7 (2018) e1356144.

10. S. Hu, H. Yuan, Z. Li, J. Zhang, J. Wu, Y. Chen, Q. Shi, W. Ren, N. Shao, X. Ying, Transcriptional response profiles of paired tumor-normal samples offer novel perspectives in pan-cancer analysis, Oncotarget. 8 (2017) 41334–41347.

11. J. Wu, S. Hu, Y. Chen, Z. Li, J. Zhang, H. Yuan, Q. Shi, N. Shao, X. Ying, BCIP: a gene-centered platform for identifying potential regulatory genes in breast cancer, Scientific Reports. 7 (2017) 45235.

12. Y. Chen, Z. Li, S. Hu, J. Zhang, J. Wu, N. Shao, X. Bo, M. Ni, X. Ying, Gut metagenomes of type 2 diabetic patients have characteristic single-nucleotide polymorphism distribution in Bacteroides coprocola, Microbiome. 5 (2017) 15.

13. W. Ren, J. Zhang, W. Li, Z. Li, S. Hu, J. Suo, X. Ying, A Tumor-Specific Prognostic Long Non-Coding RNA Signature in Gastric Cancer, Medical Science Monitor. 22 (2016) 3647–3657.

14. T. Li, L. Chen, J. Cheng, J. Dai, Y. Huang, J. Zhang, Z. Liu, A. Li, N. Li, H. Wang, X. Yin, K. He, M. Yu, T. Zhou, X. Zhang, Q. Xia, SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores, Nature Communications. 7 (2016) 12969.

15. Z. Li, Y. Chen, S. Hu, J. Zhang, J. Wu, W. Ren, N. Shao, X. Ying, Integrative analysis of protein-coding and non-coding RNAs identifies clinically relevant subtypes of clear cell renal cell carcinoma, Oncotarget. 7 (2016) 82671–82685.

 

科研项目

已完成项目:

1.2018-2020,国家科技重大专项,《基于基因组多源异构大数据的突发急性传染病预测预警关键技术研究》,子任务负责人。

 

在研项目:

1.2020-2021,天津大学北洋学者英才计划基金项目,《基于外周血RNA测序数据的结核病诊断免疫标志物研究及预测模型构建》,负责人。

 

获奖情况

2020年  入选天津大学-北洋学者英才计划

2014年  第五届中美临床与转化医学国际论坛研究生论文奖

2013年  第十二届“挑战杯”天津市大学生课外学术科技作品竞赛一等奖

 

社会学术兼职

中国免疫学会会员