副教授/副研究员

穆晓宇

职称:副研究员

邮箱:muxiaoyu@tju.edu.cn

电话:022-83612122

地址:医工院第十教学楼207室

个人简介

天津大学副研究员,硕士生导师,毕业于天津大学并获得博士学位。研究方向是纳米医学,其研究工作主要集中在神经生物材料设计、红外二区的荧光成像及其在重大神经系统疾病治疗中的应用。迄今为止,在高水平SCI期刊共发表论文40余篇,包含以第一作者或通讯作者身份发表在顶级期刊Science Advances (Science子刊)、ACS Nano、Nano Lett.、Coord. Chem. Rev.、Trends Pharmacol. Sci.、Theranostics、SmallACS Appl. Mater. Interfaces等,ESI高被引1篇,热点论文1篇。主持国家自然科学基金青年基金1项、国家重点研发计划子课题1项;作为项目骨干,参与“脑科学与类脑研究”重大项目青年科学家项目1项,国家自然科学基金重点项目、重大研究计划等4项;合作主持天津市自然科学基金面上项目2项。

 

教育背景

2013.09-2018.06,天津大学,博士.

2009.09-2013.06,天津大学,本科.

 

工作经历

2020.08-至今,天津大学医学工程与转化医学研究院,副研究员.

2018.06-2020.07,天津大学理学院物理系,博士后

 

主要研究方向

1具有生物活性的催化材料的设计合成及其医学作用机理研究。

2新型纳米酶的物理化学设计及其在重大疾病诊疗中的应用。

3新型干电极设计及其与组织界面间电子输运机制研究。


代表性学术成果

1. Xiaoyu Mu, Junying Wang, Hua He, Qifeng Li, Bing Yang, Junhui Wang, Haile Liu, Yalong Gao, Lufei Ouyang, Si Sun, Qinjuan Ren, Xinjian Shi, Wenting Hao, Qiaoman Fei, Jiang Yang, Lulin Li, Ryan Vest, Tony Wyss-Coray, Jian Luo, and Xiao-Dong Zhang*, An oligomeric semiconducting nanozyme with ultrafast electron transfers alleviates acute brain injury. Science Advances, 2021 (设计了具有超快电子转移的短聚物纳米酶,可以缓解急性脑损伤症状)。

https://www.science.org/doi/full/10.1126/sciadv.abk1210

2. Shaofang Zhang, Yonghui Li, Si Sun, Ling Liu, Xiaoyu Mu, Shuhu Liu, Menglu Jiao, Xinzhu Chen, Ke Chen, Huizhen Ma, Tuo Li, Xiaoyu Liu, Hao Wang, Jianning Zhang, Jiang Yang & Xiao-Dong Zhang*, Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma, Nature Communications, 2022 (设计了超越天然酶亲和力的单原子纳米酶).

https://www.nature.com/articles/s41467-022-32411-z

http://news.tju.edu.cn/info/1012/61947.htm

3. Shaofang Zhang; Ying Liu; Si Sun; Junying Wang; Qifeng Li; Ruijuan Yan; Yalong Gao; Haile Liu; Shuangjie Liu; Wenting Hao; Haitao Dai; Changlong Liu; Yuanming Sun; Wei Long; Xiaoyu Mu*; Xiao-Dong Zhang*, Catalytic patch with redox Cr/CeO2 nanozyme of noninvasive intervention for brain trauma. Theragnostic, 2021, 11, 2806-2821.

4. Yunguang Zhang; Simin Ni; Chenyang Chong; Jiangang Xu∗; Xiaoyu Mu∗; Xiao-Dong Zhang∗, Biocatalysts at atom level: From coordination structure to medical applications. Appl. Mater. Today. 2021, 23, 101029.

5. Xiaoyu Mu; Hua He; Junying Wang; Wei Long; Qifeng Li; Haile Liu; Yalong Gao; Lufei Ouyang; Qinjuan Ren; Si Sun; Jingya Wang; Jiang Yang; Qiang Liu; Yuanming Sun; Changlong Liu; Xiaodong Zhang*; Wenping Hu, Carbogenic Nanozyme with Ultrahigh RNS Selectivity for Traumatic Brain Injury. Nano Lett. 2019, 19, 4527-4534.

6. Xiaoyu Mu; Junying Wang; Yonghui Li; Fujuan Xu; Wei Long; Lufei Ouyang; Haile Liu; Yaqi Jing; Jingya Wang; Haitao Dai; Qiang Liu; Yuanming Sun; Changlong Liu; Xiao-Dong Zhang*, Redox Trimetallic Nanozyme with Neutral Environment Preference for Brain Injury. ACS Nano 2019, 13, 1870-1884.

7. Hao Wang#Xiaoyu Mu#; Jiang Yang; Yongye Liang; Xiao-Dong Zhang*; Dong Ming*, Brain Imaging with Near-Infrared Fluorophores. Coord. Chem. Rev. 2019, 380, 550-571. (co-First)

8. Hao Wang#Xiaoyu Mu#; Hua He; Xiao-Dong Zhang*, Cancer Radiosensitizers. Trends Pharmacol. Sci. 2018, 39, 24-48. (co-First,热点论文0.1%,ESI高被引论文)

9. Menglu Jiao#Xiaoyu Mu#, Si Sun#, Haiyu Yang, Lufei Ouyang, Shaofang Zhang, Jiao Guo, Jian Meng, Ya Liu, Huizhen Ma, Hao Wang, Jiahui Pei, Ruoli Zhao, Tianyu Liu, Wei Long, Xiao-Dong Zhang, Ruiping Zhang. Establishing bilateral modulation of radiation induced redox damage via biocatalytic single atom engineering at Au clusters. Chem. Eng. J. 2022, 445, 136793. (co-First)

10. Xiaoyu Mu; Junying Wang; Xueting Bai; Fujuan Xu; Haixia Liu; Jiang Yang; Yaqi Jing; Lingfang Liu; Xuhui Xue; Haitao Dai; Qiang Liu; Yuan-Ming Sun; Changlong Liu*; Xiao-Dong Zhang*, Black Phosphorus Quantum Dot Induced Oxidative Stress and Toxicity in Living Cells and Mice. ACS Appl. Mater. Interfaces 2017, 9, 20399-20409.

11. Junying Wang#Xiaoyu Mu#; Yonghui Li; Fujuan Xu; Wei Long; Jiang Yang; Peixian Bian; Junchi Chen; Lufei Ouyang; Haile Liu; Yaqi Jing; Jingya Wang; Lingfang Liu; Haitao Dai; Yuanming Sun; Changlong Liu; Xiao-Dong Zhang*, Hollow PtPdRh Nanocubes with Enhanced Catalytic Activities for in Vivo Clearance of Radiation-Induced ROS via Surface-Mediated Bond Breaking. Small 2018, 14, e1703736. (co-First)

12. Jiahui Pei#; Ruoli Zhao#Xiaoyu Mu#; Junying Wang; Changlong Liu*; Xiao-Dong Zhang*, Single-atom nanozymes for biological applications. Biomater. Sci. 2020, 8, 6428-6441. (co-First)

13. Haile Liu, Yonghui Li, Si Sun, Qi Xin, Shuhu Liu, Xiaoyu Mu, Xun Yuan, Ke Chen, Hao Wang, Kalman Varga, Wenbo Mi, Jiang Yang & Xiao-Dong Zhang*, Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions, Nature Communications, 2021.(提出团簇酶Clusterzyme的概念,揭示对神经炎症的调控, 入选Nature Communications的Editor Choice,入选ESI高被引)

http://news.tju.edu.cn/info/1003/54635.htm 

14. Haile Liu, Guosong Hong, Zhentao Luo, Junchi Chen, Junlei Chang, Ming Gong, Hua He, Jiang Yang, Xun Yuan, Lulin Li, Xiaoyu Mu, Junying Wang, Wenbo Mi, Jian Luo, Jianping Xie*, Xiao-Dong Zhang*, Atomic-Precision Gold Clusters for NIR-II Imaging. Adv. Mater. 2019, 31, e1901015.

15. Jiangang Xu; Ru Cai; Yunguang Zhang; Xiaoyu Mu*, Molybdenum disulfide-based materials with enzyme-like characteristics for biological applications. Colloid Surface B. 2021, 200, 111575.

16. Qifeng Li, Yalong Gao, Jun Shen, Xiaoyu Mu*, Junying Wang, Lufei Ouyang, Ke Chen, Hua He, Jiahui Pei, Qinjuan Ren, Si Sun, Haile Liu, Lei Zhou, Yuanming Sun, Wei Long, Jianning Zhang*, Xiao-Dong Zhang*. Catalase-like quantum dots of l-lysine polymerization as free radical scavengers for hypoxic brain injury. Mater. Today. Commun. 2021, 27, 102286.

17. Ruijuan Yan#, Si Sun#, Jiang Yang#, Wei Long, Junying Wang, Xiaoyu Mu, Qifeng Li, Wenting Hao, Shaofang Zhang, Haile Liu, Yalong Gao, Lufei Ouyang, Junchi Chen, Shuangjie Liu, Xiao-Dong Zhang*, Dong Ming*, Nanozyme-Based Bandage with Single-Atom Catalysis for Brain Trauma. ACS Nano 2019, 13, 11552-11560.

18. Xiaoyu Mu; Xiaoyu Liu; Xiaohu Wang; Haitao Dai; Changlong Liu*, Growth of Rutile TiO2 Nanorods in Ti and Cu Ion Sequentially Implanted SiO2 and the Involved Mechanisms. Nanotechnology 2018, 29, 025601.

 

专利:

1.  张晓东, 闫瑞娟, 孙思, 穆晓宇, 刘爽杰. 一种用于皮肤创伤的单原子纳米酶贴剂及制备方法[P]. 天津市:CN110960552A, 2020-04-07.


科研项目

1. 国家自然科学基金,青年项目, Cu-N-C单原子纳米酶神经绷带的构建及其非入侵治疗(82001952),24万,2021.1-2023.12,主持,在研。

2. 国家重点研发计划,生物与信息融合(BT-IT融合)重大专项,新一代高相容性生物植入电极设计与应用——课题2“人工酶电极传感系统的研制与性能研究”,54.69万,2021.12-2024.11,主持,在研。

3. “脑科学与类脑研究”重大项目,青年科学家项目,基于忆阻器神经形态芯片的新型脑机接口技术与应用,50万,2022.1-2026.12,项目骨干,在研。

4. 天津市自然科学基金,面上项目,基于新型抗氧化有机纳米酶分子的神经外用绷带,10万,2020.4-2023.3,合作主持,在研。

5. 天津市自然科学基金,面上项目,新型纳米酶对StandfordA型主动脉夹层术后神经系统的保护作用研究,10万,2021.4-2024.3,合作主持,在研。

6. 国家自然科学基金,面上项目,有机纳米酶分子的设计及其对外伤性脑损伤的治,55万,2020.1-2023.12,项目骨干,在研。

7. 国家自然科学基金,联合基金,电子辐射诱导增强CeO2团簇的电催化性能、催化机理及其在脑损伤中的应用,58万,2020.1-2022.12,项目骨干,在研。

8. 国家自然科学基金,重大研究计划培育项目,乳腺癌演进和分子分型的红外二区荧光成像(91859101),70万,2019.1-2021.12,项目骨干,结题。

 

获奖情况

社会学术兼职

Frontiers in Chemistry,Review Editor for Nanoscience