博士后

范华东

职称:助理研究员

邮箱:fanhuadong@tju.edu.cn

电话:022-83612122

地址:天津大学医工院办公楼104室

个人简介

范华东,1984年出生于安徽省太和县, 2015年于中国科学技术大学获工学博士学位。研究方向为神经退行性疾病,神经发育生物学及神经药理与毒理学。作为关键申请人,获批并参与美国国立卫生研究院资助的多个R01项目;作为项目骨干曾参与并完成国家自然科学基金面上项目等多个项目。目前主要集中在外泌体在疾病中的机制及转化应用研究。


教育背景

2010.09-2015.06,中国科学技术大学,博士

2007.09-2010.06,中国科学技术大学,硕士

2001.09-2006.07, 安徽医科大学,本科

工作经历

2015.10-2016.03,深圳大学高等研究院,博士后

2016.03-2020.08,美国路易斯维尔大学神经药理与毒理系,博士后

2020.11-         天津大学精密仪器与光电子工程学院,助理研究员


主要研究方向

神经退行性疾病、神经发育生物学及神经药理与毒理学。目前主要集中在:

(1)外泌体在介导疾病发生中的机制研究,包括但不限于神经系统、免疫系统及肿瘤发生

(2)营养学研究:天然水果或蔬菜来源的外泌体样纳米颗粒对抗环境中所含毒性物质的机制及应用研究

(3)分离提纯特定疾病病人的血浆外泌体,对其进行内含物的蛋白质谱、microRNA表达谱及某些免疫分子进行分析,寻找疾病相关的潜在biomarker,开发精确诊断试剂盒。


代表性学术成果

1: Li, Y.*, Fan, H.*, Lu, L., Liu, J., et al. (2020). Sulforaphane protects against ethanol-induced apoptosis in human neural crest cells through diminishing ethanol-induced hypermethylation at the promoters of the genes encoded inhibitor of apoptosis proteins. Frontiers in Cell and Developmental Biology (Under Review, Co-first author).

2: Yuan, F., Yun, Y., Fan, H., Li, Y., Lu, L., Liu, J., et al. (2020). MicroRNA-135a Protects Against Ethanol-Induced Apoptosis in Neural Crest Cells and Craniofacial Defects in Zebrafish by Modulating the Siah1/p38/p53 Pathway. Frontiers in Cell and Developmental Biology 8, 1058.

3: Fan, H., Yuan, F., Yun, Y., Wu, T., Lu, L., Liu, J., Feng, W. & Chen, S.Y. MicroRNA-34a mediates ethanol-induced impairment of neural differentiation of neural crest cells by targeting autophagy-related gene 9a. Experimental neurology 320, 112981 (2019).

4: Fan, H., Yuan, F., Wu, T., Lu, L., Liu, J. & Chen, S.Y. Exosomal Shuttling of Mir-126 from Human Neural Crest Cells Mediates Ethanol-Induced Repression of Sdf1/Cxcr4 and Disruption of Neural Crest Cell-Placode Interaction. Alcoholism-Clinical and Experimental Research 43, 161a-161a (2019).

5: Fan, H., Yuan, F., Liu, J. & Chen, S.Y. Disruption of Neural Crest Cell-Placode Interaction by down-Regulating Sdf1/Cxcr4 Signaling Mediates Ethanol-Induced Craniofacial Anomalies and Cranial Nerve Defects. Alcoholism-Clinical and Experimental Research 42, 40a-40a (2018).

6: Fan, H.D., Yuan, F.Q., Wu, T., Liu, J. & Chen, S.Y. Up-Regulation of microrna-34a Mediates Ethanol-Induced Impairment of Neural Crest Cell migration through Modulating the EMT by Targeting Snail1. Alcoholism-Clinical and Experimental Research 41, 213a-213a (2017).

7: Fan, H.D., Yun, Y., Yuan, F.Q., Liu, J. & Chen, S.Y. Microrna-34a Is Involved in Ethanol-Induced Inhibition of Neural Differentiation of Neural Crest Cells by Targeting Autophagy-Related Genes. Alcoholism-Clinical and Experimental Research 41, 213a-213a (2017).

8:Fan, H.D., Chen, S.P., Sun, Y.X., Xu, S.H. & Wu, L.J. Seipin mutation at glycosylation sites activates autophagy in transfected cells via abnormal large lipid droplets generation. Acta pharmacologica Sinica 36, 497-506 (2015).

9: Xu, S.H., Xu, S.M., Chen, S.P., Fan, H.D., Luo, X., Yang, X.Y., Wang, J., Yuan, H., Xu, A. & Wu, L.J. Graphene Oxide Modulates B Cell Surface Phenotype and Impairs Immunoglobulin Secretion in Plasma Cell. Journal of nanoscience and nanotechnology 16, 4205-4215 (2016).

10:Xu, S.H., Xu, S.M., Chen, S.P., Fan, H.D., Luo, X., Sun, Y.X., Wang, J., Yuan, H., Xu, A. & Wu, L.J. The acidic transformed nano-VO2 causes macrophage cell death by the induction of lysosomal membrane permeabilization and Ca2+ efflux. Toxicology reports 2, 870-879 (2015).

11:Ying, Z., Wang, H.F., Fan, H.D. & Wang, G.H. The Endoplasmic Reticulum (ER)-associated Degradation System Regulates Aggregation and Degradation of Mutant Neuroserpin. Journal of Biological Chemistry 286, 20835-20844 (2011).

12:Wang, X.J., Fan, H.D., Ying, Z., Li, B., Wang, H.F. & Wang, G.H. Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system. Neuroscience letters 469, 112-116 (2010).

13:Wang, G.H., Ying, Z., Wang, H.F. & Fan, H.D. Gp78 promotes sod1 degradation. Neurosci Res 68, E198-E198 (2010).

14:Ying, Z., Wang, H.F., Fan, H.D., Zhu, X.D., Zhou, J.W., Fei, E.K. & Wang, G.H. Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation. Human molecular genetics 18, 4268-4281 (2009).


科研项目

2020-2025,美国国立卫生研究院R01项目:“Role of exosomes in the coordinated migration of neural crest cells and placodes and ethanol-induced teratogenesis”(200万美元),项目关键申请人。

2013-2019,美国国立卫生研究院 R01项目:“Role of microRNAs in Ethanol-induced Apoptosis and Teratogenesis”(200万美元),项目骨干。

2013-2016,国家自然科学基金面上项目: “自噬系统调控胞间通讯对辐射诱导非靶区肿瘤细胞凋亡的影响”(85万元),第一参与人。

2011-2012,国家自然科学基金青年基金项目:“Ataxin3介导的K63位去泛素化促进神经退行性疾病相关蛋白的聚集”(20万元), 主要参与人。

2008-2009国家自然科学基金青年基金项目:“SUMO化修饰影响fALS相关蛋SOD1聚集的机制研究”(20万元),主要参与人。


获奖情况

1:2017年:获美国第40届酒精滥用研究协会科学年会初级研究员奖(Junior Investigator Award for the 40th Annual Scientific Meeting of Research Society on Alcoholism, June 24-28, 2017. Denver, Colorado, USA.)。

2:2018年:获美国第41届酒精滥用研究协会科学年会初级研究员奖(Junior Investigator Award for the 41th Annual Scientific Meeting of Research Society on Alcoholism, June 16-20, 2018. San Diego, California, USA.)。

3:2019年:获美国第42届酒精滥用研究协会科学年会初级研究员奖(Junior Investigator Award for the 42nd Annual Scientific Meeting of Research Society on Alcoholism, June 22-26,2019. Minneapolis, Minnesota, USA.)。


社会学术兼职

2017-2020: 美国酒精滥用研究协会(Research Society on Alcoholism, USA):会员。

2020.02-2022.02:《American Journal of Psychiatry and Neuroscience》:编委。

《Human Reproduction》(IF=5.506):审稿人。

《Oxidative Medicine and Cellular Longevity》(IF=4.868):审稿人。