副教授/副研究员

董津睿

职称:副教授

邮箱:jinrui_dong@tju.edu.cn

电话:022-83612122

地址:天津大学10号教学楼213室

个人简介

董津睿,博士,副教授,天津大学“北洋学者英才计划”入选者。本科毕业于南开大学生物科学系,博士毕业于新加坡国立大学药理系,于杜克-新加坡国立大学医学院从事博士后研究,现就职于天津大学医学工程与转化医学研究院。主要研究方向为呼吸系统疾病和肝损伤疾病的发病机制及新型药物靶点研发。研究成果发表在Science Translational Medicine、Nature Communications、eLife、Circulation、Gastroenterology等学术期刊。

教育背景2

2013.08-2017.12 新加坡国立大学 杨潞龄医学院药理系 博士

2009.09-2013.06 南开大学 生命科学学院生物科学系 本科

工作经历

2021.11-至今 天津大学 医学工程与转化医学研究院 副教授

2018.01-2021.10 杜克-新加坡国立大学医学院 博士后


主要研究方向

1. 炎症性肺病(哮喘和慢性阻塞性肺损伤)的发病机制研究和小分子药物研发

2. 间质性肺病的发病机制研究和肺纤维化抗体药物研发

3. 非酒精性脂肪性肝炎的抗体药物研发和脂毒性肝损伤的病理机制研究

4. 药物性肝损伤的病理机制研究和新型药物靶点研发


代表性学术成果

1. Jinrui Dong; Sivakumar Viswanathan; Eleonora Adami; Sebastian Schafer; Fathima F. Kuthubudeen; Anissa A. Widjaja; Stuart A. Cook; The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling, eLife, 2021, 10: e68843.

2. Anissa A. Widjaja#; Jinrui Dong#; Eleonora Adami; Sivakumar Viswanathan; Benjamin Ng; Leroy S. Pakkiri; Sonia P. Chothani; Brijesh K. Singh; Wei Wen Lim; Jin Zhou; Shamini G. Shekeran; Jessie Tan; Sze Yun Lim; Joyce Goh; Mao Wang; Robert Holgate; Arron Hearn; Leanne E. Felkin; Paul M. Yen; James W. Dear; Chester L. Drum; Sebastian Schafer; Stuart A. Cook; Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury, Science Translational Medicine, 2021, 13(597).

3. Jinrui Dong; Sivakumar Viswanathan; Eleonora Adami; Brijesh K. Singh; Sonia P. Chothani; Benjamin Ng; Wei Wen Lim; Jin Zhou; Madhulika Tripathi; Nicole S. J. Ko; Shamini G. Shekeran; Jessie Tan; Sze Yun Lim; Mao Wang; Pei Min Lio; Paul M. Yen; Sebastian Schafer; Stuart A. Cook; Anissa A. Widjaja; Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH, Nature Communications, 2021, 12(66): 1-15.

4. Benjamin Ng#; Jinrui Dong#; Giuseppe D’Agostino#; Sivakumar Viswanathan; Anissa A. Widjaja; Wei-Wen Lim; Nicole S. J. Ko; Jessie Tan; Sonia P. Chothani; Benjamin Huang; Chen Xie; Chee Jian Pua; Ann-Marie Chacko; Nuno Guimarães-Camboa; Sylvia M. Evans; Adam J. Byrne; Toby M. Maher; Jiurong Liang; Dianhua Jiang; Paul W. Noble; Sebastian Schafer; Stuart A. Cook; Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis, Science Translational Medicine, 2019, 11(eaaw1237).

5. Jinrui Dong#; Wupeng Liao#; Lay Hong Tan; Amy Yong; Wen Yan Peh; W. S. Fred Wong; Gene silencing of receptor-interacting protein 2 protects against cigarette smoke induced-acute lung injury, Pharmacological Research, 2018, 139(2019): 560-568.

6. Jinrui Dong; Wupeng Liao; Hong Yong Peh; W. S. Daniel Tan; Shuo Zhou; W. S. Fred Wong; Ribosomal Protein S3 siRNA ameliorates cigarette smoke induced-acute lung injury, Molecular Therapy-Nucleic Acids, 2018, 12: 370-380.

7. Jinrui Dong; Wupeng Liao; Hong Yong Peh; Tze Khee Chan; W. S. Daniel Tan; Li Li; Amy Yong; W. S. Fred Wong; Ribosomal Protein S3 gene silencing protects against experimental allergic asthma, British Journal of Pharmacology, 2017, 174(7): 540-552.

8. Benjamin Ng; Jinrui Dong; Sivakumar Viswanathan; Anissa A. Widjaja; Bhairav S. Paleja; Eleonora Adami; Nicole S. J. Ko; Mao Wang; Stella Lim; Jessie Tan; Sonia P. Chothani; Salvatore Albani; Sebastian Schafer; Stuart A. Cook; Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease, The FASEB Journal, 2020, 34(9): 11802-11815.

9. Sonia Chothani#; Sebastian Schafer#; Eleonora Adami#; Sivakumar Viswanathan; Anissa A. Widjaja; Sarah R. Langley; Jessie Tan; Mao Wang; Nicholas M. Quaife; Chee Jian Pua; Giuseppe D’Agostino; Shamini Guna Shekeran; Benjamin L. George; Stella Lim; Elaine Yiqun Cao; Sebastiaan van Heesch; Franziska Witte; Leanne E. Felkin; Eleni G. Christodoulou; Jinrui Dong; Susanne Blachut; Giannino Patone; Paul J. R. Barton; Norbert Hubner; Stuart A. Cook; Owen J. L. Rackham; Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins, Circulation, 2019, 140(11): 937-951.

10. Anissa A. Widjaja#; Brijesh K. Singh#; Eleonora Adami#; Sivakumar Viswanathan; Jinrui Dong; Giuseppe A D'Agostino; Benjamin Ng; Wei Wen Lim; Jessie Tan; Bhairav S. Paleja; Madhulika Tripathi; Sze Yun Lim; Shamini Guna Shekeran; Sonia P. Chothani; Anne Rabes; Martina Sombetzki; Eveline Bruinstroop; Lio Pei Min; Rohit A. Sinha; Salvatore Albani; Paul M. Yen; Sebastian Schafer; Stuart A. Cook; Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis, Gastroenterology, 2019, 157(3): 777- 792.


科研项目

2020.6-2022.5,勃林格殷格翰(Boehringer-Ingelheim)科研合作项目,NUS Ref: 2020-0645,Investigating the signaling and function of the IL11 pathway,252万新币,在研,主要参与人。


获奖情况

2021,天津大学北洋学者英才计划

2017,天然产物科学前沿2017年国际会议最佳墙报展示奖

2017,新加坡国立大学医学院第七届研究生科学大会最佳墙报展示奖

2016,新加坡国立大学医学院第六届研究生科学大会最佳墙报展示奖

2013-2017,新加坡国立大学研究生奖学金


社会学术兼职

新加坡药理学协会会员

欧洲呼吸协会(ERS)会员

美国胸腔协会(ATS)会员